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Replenishing the nutritional status of the host by increasing vital amino acids such as cysteine to enhance GSH levels and selenium to improve selenium deficiency and facilitate selenoprotein (GSH peroxidases, thioredoxin reductases) expression can inhibit oxidative stress, modulating inflammation, suppressing endothelial dysfunction, and protecting vascular cells against apoptosis and calcification (He et al., 2017

10.1093/embo-reports/kvf099 EMBO Rep

These findings underscore the necessity of a holistic approach to CSC research, leveraging multiomics data to overcome the challenges posed by CSC heterogeneity and plasticity