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78 Augmented cAMP signaling might not only strengthen classical cAMP/PKA pathways but could also modulate cAMP/Epac-dependent pathways, including PI3K/Akt, which have been associated with aspects of cellular survival, mitochondrial bioenergetics, and autophagy in preclinical studies

In colorectal cancer models (e.g., HT29, HCT116), sertraline exhibited IC 50 between 2.4 and 14.7 M and outperformed traditional chemotherapeutics in multidrugresistant cell lines [21, 87]

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