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Thus, postprandial PYY release under normal physiological conditions is likely to be mediated through paracrine and neural mechanisms (123)

3.4 Thiazolidinediones (Glitazones) Thiazolidinediones (glitazones) activate the peroxisome proliferator-activated receptor (PPAR) gamma, triggering a complex set of metabolic changes centred around lipid metabolism, primarily in adipocytes but also in a wide range of other tissues, including skeletal muscle [120]