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This reduces appetite, lowers blood sugar, and helps lead to significant weight loss
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Although initial findings suggest that GLP-1Ra leads to a slight reduction in bone mineral density and promotes bone remodeling, favoring resorption similar to calorie restriction effects, further research is needed to explore the effects of GLP-1Ra on bone metabolism and fracture-related outcomes, as well as dual- and triple-receptor agonists of GLP-1, glucose-dependent insulinotropic polypeptide (GIP), and glucagon in PwO
Patients taking tirzepatide in both trials had a 1617% reduction in body weight, along with improvements in OSA-specific hypoxic burden, and high sensitivity C-reactive protein (a biomarker of systemic inflammation and cardiovascular risk) [113, 114]
