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Together, these findings suggest that cellular resistance to cuproptosis also depends on a hierarchically organized copper-buffering system, in which mtGSH provides rapid, dynamic metal buffering, whereas metallothioneins confer sustained high-affinity sequestration to prevent mitochondrial copper overload

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It was hypothesized that NASO B12 will be more effective in treating the deficiency of vitamin B12, when compared with oral methylcobalamin in patients receiving metformin