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N Engl J Med 345(12):851860 Brenner BM, Cooper ME, de Zeeuw D, Keane WF, Mitch WE, Parving H-H et al (2001Effects) Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy

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In both trials, during the 10-day treatment period, subjects should not have consumed alcohol, liquids or food containing poppy seeds, grapefruit (dosing conditions trial), caffeine or other xanthines, changed their exercise pattern or daily routines (dosing conditions trial) or performed strenuous physical exercise (food-effect trial)