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Biomolecules (2016) 6(1):6

Furthermore, studies have reported an aberrant activation of NRF2, a key antioxidant transcription factor involved in the regulation of critical antioxidants including glutathione, SOD, and CAT, leading to reduced antioxidant capacity ( 4 Immune dysregulation and neuroinflammation in ASD ASD itself is related to altered neuroinflammatory mechanisms and unusual immune responses

Volpe S, Lisco G, Fanelli M, Racaniello D, Colaianni V, Triggiani D, Donghia R, Crudele L, Rinaldi R, Sabb C, Triggiani V, De Pergola G, Piazzolla G

Need to avoid CITRUS* then skip the BURN Capsule: Need to avoid BERBERINE* (phytosomal) skip the CONTROL Capsule: These statements have not been evaluated by the Food & Drug Administation