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Reynolds, and Altria have opposed policies across the country that are proven to decrease cigarette demand and have undermined efforts to enact these types of regulations, such as higher taxes, flavor bans, graphic warning labels and clean indoor air laws

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In the past few years, there has been increased interest in employing cannabis-based products as therapeutics, simultaneously with an increase in the flexibility in laws and regulations regarding the personal use of cannabis [8,9,10]