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Glutathione S-transferases (GSTs) (the Enzyme Commission (EC) number: EC 2.5.1.18) are phase II metabolic enzymes, 3 which play essential roles in xenobiotic biotransformation, 4 drug metabolism, 5 protection against oxidative stress, and regulating cell proliferation and signaling pathways

The process begins in the hypothalamus , a region of the brain that releases signaling molecules that communicate with the pituitary gland