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Another study developed GelMA hydrogel microneedles loaded with FeO/MXene heterojunctions, which exhibit site-dependent ROS targeting: they scavenge extracellular ROS while releasing Fe/Fe to enhance intracellular ROS and induce bacterial ferroptosis, demonstrating potent antibacterial activity and wound-healing promotion in diabetic infected wounds [98]

Therapeutic innovation now includes dual and triple incretin receptor agonists [4,5,6,7] as well as orally bioavailable small-molecule formulations [8, 9], reflecting ongoing efforts to enhance pharmacodynamic durability

We also acknowledge Biorender.com ( Figure 1 )

Retinoic acid and immune homeostasis: a balancing act