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DOI: 10.1097/JU.0000000000003999

Proc Natl Acad Sci USA 111 , E12111220, doi:10.1073/pnas.1321347111 (2014)

Clinicians should focus on established adverse effects such as gastrointestinal symptoms, pancreatitis risk, and thyroid considerations rather than unsubstantiated neurological concerns

What's more important really is to understand the general principles of how something like pleasure and pain work, how they interact, and the various cells and systems within the brain and body that allow them to occur, and that modulate or change their ability to occur

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