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Additional exploratory applications include neuroprotection through enhanced brain energy metabolism and immune modulation, as preliminary work suggests anti-inflammatory actions in experimental models

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In Canada, Wegovy is indicated as an adjunct to a reduced calorie diet and increased physical activity for chronic weight management in adult patients with an initial body mass index (BMI) of 30 kg/m 2 or greater (obesity), or 27 kg/m 2 or greater (overweight) in the presence of at least one weight-related comorbidity such as hypertension, type 2 diabetes mellitus, dyslipidemia, or obstructive sleep apnea