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Traditionally, population-based TK modelling approaches are conducted on one chemical at a time, but new approaches employing high-throughput in vitro testing and computational modelling to predict internal exposures - including quantitative estimates of population variability - have been employed on environmental xenobiotics (Jamei et al

Within the membrane of the enterocytes are active transport channels that enable the cell to pump some of xenobiotics that have entered by diffusion back into the intestinal lumen (Figure 2.2)

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