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However, blocking NF-B may bring about undesirable side effects, such as the broad suppression of innate immunity due to the lack of specificity of the relevant treatment and the significance of NF-B in cellular homeostasis (66)

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It is noteworthy that high concentrations of PLP can regulate intracellular PLP levels by inhibiting the activity of PNPO enzyme, whereas mutant enzymes with residual activity cannot be regulated by PLP negative feedback

A doctor may recommend this test to people who have symptoms of a deficiency or who have a higher risk of low vitamin B12 in the body