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Approach Extended Duration 8-12 weeks Off Period 4 weeks Notes Reported with slow titration

Morphologically, aged LCs appear normal but exhibit signs of dedifferentiation and degeneration, including poorly developed endoplasmic reticulum and mitochondria, increased lipofuscin granules, abnormal cytoplasmic lipid droplets, and multiple nuclei [56, 65]

Liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based quantitative methods are one of the most commonly used techniques, with the advantage of being able to efficiently separate and detect a variety of carnitine and its derivatives, including free carnitine, acylcarnitine, and their isomers and odd forms

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