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In addition, the synthetic retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) is an inhibitor of PolA1 and selectively induces apoptosis in human lung cancer cells (Sun et al., 2002)

A pro-oxidative shift caused by GSH depletion triggers glutathionylation of CASP8 at residues Cys360 and Cys409 81

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Vitamin E promotes the strengthening of endogenous antioxidant defences and can protect the pancreas, kidneys, eyes and nervous system in animal models from oxidative stress (Pazdro and Burgess, 2010)