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This means NPs in primary care, endocrinology, and obesity medicine can independently evaluate patients and prescribe semaglutide without physician co-signature

A third, recent study in JAMA Network Open , from August of 2025, analyzed data from 159,000 people with type 2 diabetes who took semaglutide or tirzepatide (Mounjaro, Zepbound)

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After a trial and error, they might stop the medication for a few weeks to see if mental health improves and then you restart the medication