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Any of these signs mean the solution should be discarded

Despite these promising findings, current evidence is preliminary, and the mechanistic basis for any comparative or synergistic advantages remains speculative

J Chem Ecol 29:21772182 McLean MD, Yevtushenko DP, Deschene D, Van Cauwenberghe OR, Makhmoudova A, Potter JW, Bown AW, Shelp BJ (2003) Overexpression of glutamate decarboxylase in transgenic tobacco plants confers resistance to the northern root-knot nematode

The rationale is mechanistic non-overlap: rather than two compounds acting through the same pathway with redundant effects, BPC-157 and TB-500 engage distinct targets the former operating through nitric-oxide-pathway and VEGFR2 modulation, the latter through actin-cytoskeleton regulation