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In blood, most IGF-1 is not merely bound to a single IGFBP

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Vitamin D Optimization Given the association between vitamin D deficiency and fibroid prevalence, and the antiproliferative effects of 1,25-dihydroxyvitamin D3 on leiomyoma cells in animal models, assessing and correcting vitamin D status is a reasonable, low-risk intervention. Endocrine-disrupting chemicals (EDCs) have been shown to interact with vitamin D pathways in fibroid pathogenesis. 6

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