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Clascoterone antagonizes dihydrotestosterone (DHT) through competitive binding with cytoplasmic androgen receptors as it shares the same fused four-ring backbone structure (195)

Resveratrol, a polyphenol in grapes and red wine, was shown to reduce body weight gain in high-fat-fed rodents and restore rhythmic oscillation of leptin and insulin, essentially re-synchronizing metabolic hormones that had lost clear rhythms due to diet-induced obesity

Leveraging nuclear factor erythroid 2-related factor 2 (Nrf2) pathway Nrf2 is a ubiquitously expressed transcription factor that regulates the expression of around 20 antioxidant genes to provide protection against oxidative stress