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If a patient still has opioids present which are full agonists (use of short acting opioid less than 12 hours ago or long-acting opioid use, such as methadone, less than 48 hours ago), administration of buprenorphine, a partial mu agonist, will displace the full agonist and precipitate withdrawal symptoms

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug

If incorporating a retinoid, use only low-concentration, eye-specific formulations and introduce them gradually

Incorrect reconstitution can result in particle formation, incorrect concentration, or pH changes that all affect injection comfort