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Nanoprobe-based GSH imaging relies on signal-generating reactions triggered by glutathione, and effective tumor visualization requires that these signals clearly differentiate malignant tissue from normal tissue

For example in older mice, damage in the antioxidant system occurs, and is associated with lower mitochondrial GSH (Shi et al., 2010) and superoxide dismutase activities in the neocortex (Wang et al., 2015), as well as decreased GSH/GSSG ratio in the cortex, striatum, hippocampus and cerebellum (Rebrin et al., 2007)

Recurrent pregnancy loss (RPL), defined as three or more consecutive pregnancy losses, affects 0.52% of women in childbearing age [1]

The pH titration experiments were performed in 100 mM HEPES, 150 mM NaCl 2 , 0.5 mM MgCl 2 and pH between 6 and 9 adjusted by KOH, with the actual pH measured post-hoc