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The trial did report a skin-related effect, described as cutaneous hyperesthesia and skin sensitivity, in about 7% of people on retatrutide compared with 1% on placebo, but it did not report alopecia or hair loss as a distinct side effect

268 Inflammatory cytokines (e.g., IL-6 and TNF-) upregulate the expression of CYP24A1 in colon cancer cells by activating the NF-B pathway, which in turn leads to abnormal activation of the Wnt/-catenin pathway and promotes disease progression

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