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Notably, FoB persist in Gclc -deficient mice and are characterized by increased ROS and acquire characteristics of Gclc -sufficient MZB

The GSH/GSSG ratio serves as a primary determinant of the cellular redox state, as reduced GSH is thought to repair oxidative damage to protein thiols and to support redox signaling, the regulation of cell proliferation, control of the cell cycle, initiation of apoptosis, modulation ofthe immune response, and maintenance of skin pigmentation

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Regulation of autophagy and the ubiquitinproteasome system by the FoxO transcriptional network during muscle atrophy