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Although we cannot rule out a contribution of glycolysis to this ATP increase and did not directly assess the activity of other complexes, we observed increased 5FU sensitivity with inhibitors of ETC complexes IIV, genetic ablation of CI and CIV, and sensitizer genes from CRISPR screening covering additional complexes (CIII and CV)

In practical terms, this means a person starting at 120 kg could lose close to 29 kg on average over about a year, provided they tolerate and remain on the full dose

Safety, Provider Guidance, and Who Should Consider Evening Dosing Evening timing is safe for most patients, provided you maintain consistent weekly scheduling