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However, the FDA label explicitly states that "it is unknown whether GLP-1 receptor agonists cause thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans, as the human relevance of GLP-1 receptor agonist-induced rodent thyroid C-cell tumors has not been determined." The rodent thyroid has substantially more C-cells than the human thyroid, and rodents may be more susceptible to this effect

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Yet, only some real-world studies have assessed outcomes of semaglutide use over more than six months, limiting its clinical use

That means the total active drug in your body at any given time is about 60% higher than what a single dose alone would produce