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KPV complements these mechanisms by suppressing NF-?B activity, reducing TNF-

Shabanzadeh and colleagues (19) found that intraperitoneal pre-treatment of zinc alone or in conjunction with the GABA A antagonist, bicuculline had detrimental effects on neurological deficits and the development of the infarct following induction of focal ischemia

Therefore, the antioxidant species were used at different doses, so further clinical studies are needed to identify the minimum useful dose to be used as monotherapy or in combination with conventional therapies