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8 Remaining Questions and Knowledge Gaps There is strong evidence that synovitis drives worse outcomes in osteoarthritis, contributing to more severe and persistent pain, heightened pain sensitization, faster structural deterioration, and an increased need for joint replacement

The Netherlands Tesamorelin Ipamorelin combination could also potentially improve overall metabolic health, skin tone, deep sleep quality, and immune function

The Cochrane Collaboration's tool for assessing risk of bias in randomised trials

The need for lab work depends on your medical history, current conditions, medications, and recent test results