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In January, writer Johann Hari published a series of personal stories in outlets like The Guardian and the Huffington Post in which he claimed that antidepressant medications didn't help him because "the whole idea that depression is caused by a 'chemically imbalanced' brain is wrong." Fortunately, a large new review of 500 studies comprising more than 100,000 people and published this week in the medical journal The Lancet, backs up what many experts in the fields of psychiatry and neuroscience have been saying for decades: antidepressants do work