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The angiogenic effect is not direct on isolated cells in culture but appears in vivo when blood vessels and surrounding tissue are present (Brcic et al., 2009)

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You can read the abstract of this article at In the SURPASS-4 trial, the dual GIP and GLP-1 receptor agonist tirzepatide demonstrated superior reductions in HbA1c concentrations, bodyweight, and blood pressure compared to titrated daily insulin glargine in individuals with type 2 diabetes and cardiovascular risk

Other animal experiments linked DSIP with changes in endogenous enkephalin signalling