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Its multifaceted mechanism of action, encompassing weight reduction, metabolic normalization, and marked hepatic fat clearance, underscores its potential role in the further investigation of metabolic liver diseases

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Centrally, these medications may affect brain appetite centers through multiple pathways, including signaling via vagal afferents and action on circumventricular organs (brain regions with a more permeable blood-brain barrier)

FDA will scrutinize existing TRIUMPH-1 and TRIUMPH-4 data for any cardiovascular safety signals in the meantime