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As expected, these signals were sensitive to imatinib treatment only in WT-Bcr-Abl-32D cells but not T315I-Bcr-Abl-32D cells, while ponatinib 27 treatment abolished these signals in both cell lines (Supplementary Fig

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Furthermore, the lack of large-sample long-term experimental data results in undefined efficacy and safety of Fer-1 for DR at different stages, further reducing the practical translational value of this agent