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Finally the weight lost by the group of 1mg dose was slightly more than that achieved by the worlds largest selling prescription obesity medication in similar trials over the same period, without its troublesome side effects

these factors make GLP-1 RAs an alternative initial treatment option, with or without metformin based on glycemic needs, in T2DM patients with indicators of high-risk or established heart failure (HF) or CKD who cannot tolerate an SGLT2 inhibitor

The only human trial ever registered (NCT02637284) was cancelled in 2016 without publishing results

This is most relevant in patients with pernicious anaemia receiving initial replacement therapy and requires monitoring of electrolytes