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Alternative Role of Hypomethylation An alternative explanation for hyperhomocysteinemia-induced vascular disease is that elevated homocysteine levels indicate an inefficiency of essential intracellular methylation reactions, which may predispose to vascular disease

Depending on the chosen target(s), the review analyzed more than 80 distinctive targets, which were used in previous NO-agents studies with triple regimen, and the particular effectiveness of the given NO-agent(s) (aggravation (mostly L-NAME), protection (mostly L-arginine), and no effect (either L-NAME alone or L-arginine alone, or both, or combination L-NAME + L-arginine) [97]

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