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Why GLP-1 Medications May Trigger Headaches GLP-1 receptor agonists work by slowing gastric emptying and signaling fullness to your brain, which can shift blood flow patterns and alter fluid balance in ways that trigger head pain

These can include a flushed or cool sensation, a dry or metallic taste in the mouth, increased urination, or mild fatigue/drowsiness

2 Due to these benefits, this class of medications is currently being investigated in clinical trials for Alzheimer disease and Parkinson disease

Simultaneously, it appears to maintain a significant affinity for GHRH receptors, similar to the affinity exhibited by CJC-1295 without DAC