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2.8.1 Acute smoke model For the acute smoke model, we first analyzed the BALF and lung tissue samples from the smoke-exposed and air control animals

In MMP2 , the homozygous genotype T of the polymorphism rs243865 (C-1306T), located in the intron, shows a significant association with the FEV1 decrease in Caucasian populations 127 , while in Tunisian populations, it was correlated with disease severity 128

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