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GLP-1 boosts insulin secretion from pancreatic beta cells in a glucose-dependent manner (meaning it only works when blood glucose is elevated, reducing hypoglycemia risk), suppresses glucagon secretion from pancreatic alpha cells (reducing glucose production by the liver), slows gastric emptying (prolonging satiety and reducing postprandial glucose spikes), and starts GLP-1 receptors in the brain (very the hypothalamus) to reduce appetite and food intake

Do not use if you or your family have a history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2)

Different GLP-1 medications reach steady-state concentrations at different ratesliraglutide within approximately 3 days, dulaglutide within 2-4 weeks, and semaglutide within 4-5 weeks, according to their respective MHRA-approved prescribing information

Pardeshi, C