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SURMOUNT-1 (NCT04184622) Study Title: "Tirzepatide Once Weekly for the Treatment of Obesity" Status: Completed Phase: Phase 3 Enrollment: 2,539 participants Study Period: 2019-2021 Location: Multi-national, 119 sites Design: Randomized, double-blind, placebo-controlled Duration: 72 weeks Intervention: Tirzepatide 5/10/15 mg SC weekly vs

At nearly 5000 Da, it approaches the upper limit of what intranasal delivery can effectively handle

It is directly injected into the muscle which helps to relax the muscles gradually

Conclusions In the GOLDEN studies, the investigational drug/device combination of nebulized long-acting glycopyrrolate/eFlow CS 25mcg and 50mcg, administered twice daily, resulted in significant improvements in HRQoL as measured by SGRQ in patients with moderate to very severe COPD