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Similar content being viewed by others Introduction In the last two decades, glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) dual agonists (dualAGs) have emerged as potential pharmacological approaches to treat obesity and overcome the risks associated with bariatric surgery 1 , as well as limitations in implementing a healthy life-style in population living with obesity

"Bypasses the Barrier" Isn't the Same as "More Effective" It's mechanically true that injection delivers a peptide past the stratum corneum, the skin barrier that limits how much of anything applied topically actually gets through

This includes gallstones and gallbladder inflammation, which can develop even without a prior history of gallbladder problems