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Hormonal changes are also the reason many women experience side effects during early pregnancy such as nausea, lightheadedness, cramping, and body aches
In a subgroup analysis of based on different semaglutide medications, there was an increased risk for NAION in patients who received stand-alone Ozempic (semaglutide, Novo Nordisk) (HR = 6.27
Body Weight and Composition GLP-1 receptor agonists are dosed based on fixed amounts rather than weight-adjusted dosing (unlike insulin)
Given how hard it is to get these medications for some patients, this can be an attractive alternative, but the FDA has expressed concern at the frequency of -glutide salts turning up in compounded formulations, which are not present in any of the FDA-approved drugs and thus have an unknown safety and efficacy profile
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