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Therefore, we dissected the pathological mechanisms underlying granulosa cells dysfunction in PCOS by integrating insights from both cellular senescence and sphingolipid metabolism disorders, and explored new biomarkers for PCOS-related anovulation and potential therapeutic strategies based on bioinformatics analysis combining machine learning
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Oxidative stress resulted in the oxidation of four amino acid residues of GSDMD in macrophages and significantly improved the cutting efficiency of caspase-1 on GSDMD (154)
As a result, some injuries may take months to improve and occasionally fail to heal as expected
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