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UAB neuroscientist Andrew Hardaway explained: "Food simply becomes less rewarding

The results: Treatment duration: 72 weeks Average weight loss: Up to 22-22.5% at the 15mg dose High responders: A substantial proportion achieved 20-25% body weight reduction Dose response: Clear dose-dependent effects, with 15mg producing the greatest average weight loss SURMOUNT-5 comparisons When Mounjaro 15mg was compared directly with Wegovy 2.4mg in SURMOUNT-5-type analyses, Mounjaro showed greater weight lossaround 20.2% versus 13.7% at 72 weeks

In vivo inhibition of glutathione synthesis decreases neuronal density and alters myenteric plexus neurochemical coding

Takeaway for pharma strategy folks: This is a classic case where demand visibility is strong (12-24 months+), but execution timelines and compliance readiness will separate the winners